Pelagic MPAs: The devil is in the details

Pelagic MPAs: the devil is in the details.

The Devil Is in the Details

The notion of “vulnerable atherosclerotic plaque” introduced many years ago1,2 has been since used frequently and liberally, including by this investigator.3 We generally use this phrase to refer to intact lesions that look similar to those previously found to be disrupted and complicated by thrombosis on pathological examination. In doing so, we assume that given enough time or the right stimu...

The Devil in the Details

1. Dean LS, Rogers RP 3rd, Harley RA, Hood DD: Case scenario: Amniotic fluid embolism. ANESTHESIOLOGY 2012; 116:186 –92 2. Annecke T, Geisenberger T, Kürzl R, Penning R, Heindl B: Algorithm-based coagulation management of catastrophic amniotic fluid embolism. Blood Coagul Fibrinolysis 2010; 21:95–100 3. Leighton BL, Wall MH, Lockhart EM, Phillips LE, Zatta AJ: Use of recombinant factor VIIa in ...

Blinding in pharmacological trials: the devil is in the details

While the methodological principle of ‘blinding’ for minimising bias in randomised controlled trials (RCT) is widely debated and accepted, rarely is this depth of thinking applied to its correct handling with respect to design, reporting and analysis. Beyond the general comprehension of the definition of the word, the practical aspects of establishing blinding in investigator-initiated pharmaco...

The role of dispensaries: the devil is in the details.

INTRODUCTION Relying on results from Pacula et al. (2013), Pacula and Sevigny argue that medical marijuana dispensaries increase the consumption of marijuana, increase the consumption of alcohol, and lead to more alcohol-related traffic fatalities. Below, we will: • Argue that the dispensary indicator used by Pacula et al. (2013) is essentially unrelated to whether dispensaries were actually in...